Basic Theo 24 Sr Information

• INN (International Nonproprietary Name): Theophylline
• Brand Names Available in Canada: Theo-24®
• ATC Code: R03DA04
• Forms & Dosages: Extended-release capsules (100 mg, 200 mg, 300 mg, 400 mg)
• Manufacturers in Canada: Pfizer, UCB Pharma
• Registration Status in Canada: Prescription only
• OTC / Rx Classification: Rx only

Critical Warnings & Restrictions In Canada

When considering the use of Theo-24, it's crucial to prioritize safety by adhering to Health Canada regulations. This ensures both efficacy and minimizes potential risks associated with the medication. The following groups are identified as high-risk and warrant close monitoring:

• Elderly: Will require careful observation for any adverse effects and potential dose adjustments based on individual response and tolerance.
• Pregnant Women: It's critical that anyone pregnant consults healthcare professionals before using Theo-24, due to unknown risks associated with its use during pregnancy.
• Indigenous Populations: Respect for cultural considerations and traditional approaches to healthcare is vital, ensuring that integration with modern practices does not diminish cultural identities.

These groups require vigilance, making healthcare provider input essential in determining the best course of action, particularly as dosage and administration can significantly impact outcomes.

High-Risk Groups (Elderly, Pregnant, Indigenous Health Considerations)

Specific recommendations for high-risk populations using Theo-24 include:

• Elderly patients: Initiate treatment at a lower dose (for example, starting with 300 mg daily) to reduce the risk of adverse reactions. Regular monitoring of serum levels is recommended to avoid toxicity.
• Pregnant women: Consult healthcare professionals before commencing treatment. Adaptations or alternatives may be more suitable based on health assessments.
• Indigenous populations: Engage local healthcare professionals who understand community traditions to address healthcare needs effectively, blending them with modern medicine.

It's critical that understanding and respect inform healthcare delivery, particularly within high-risk populations, ensuring comprehensive care frameworks that promote optimal health outcomes.

Interaction With Activities (Driving, Machinery, Workplace Safety Under Canadian Law)

Engaging in activities that require mental alertness—such as driving or operating machinery—demands caution when using Theo-24. The medication may cause side effects, including restlessness or dizziness, which could impact an individual’s ability to concentrate or respond quickly. It is important to prioritize safety by:

• Avoiding depth focus in demanding tasks immediately after ingesting the medication.
• Monitoring how Theo-24 affects personal reaction times before undertaking activities that require complete focus.
• Discussing with a healthcare provider about occupational safety measures while on Theo-24.

Q&A — “Can I Drive After Taking It In Canada?”

Brief answer: Wait at least several hours after taking your dose—consult your doctor for tailored advice.

Mechanism & Pharmacology

Theophylline, the active ingredient in Theo-24, operates primarily as a bronchodilator, which means it helps to open the airways in the lungs. Understanding its mechanism involves looking at how it relaxes muscles in the respiratory tract and reduces inflammation. Theophylline blocks the enzyme phosphodiesterase leading to increased levels of cyclic AMP. This action contributes to relaxation of bronchial smooth muscle and improved airflow, making it beneficial for people suffering from asthma and chronic obstructive pulmonary disease (COPD).

In addition, Theo-24's pharmacology indicates that it can stimulate the respiratory centre in the brain, enhancing the rate and depth of breathing. As a xanthine derivative, it may also provide mild diuretic properties. Due to its complex metabolism involving liver enzymes, individual response may vary, necessitating careful dose adjustments based on serum levels, especially in populations such as the elderly or those with liver impairments.

Simplified explanation (patient-friendly)

Theo-24 works by relaxing the muscles around the airways, enabling easier breathing. Think of it like opening a window wider to let in fresh air. This effect is crucial for managing symptoms of asthma and other lung conditions as it helps reduce tightness in the chest, coughing, and shortness of breath.

Clinical terms (Health Canada approved monograph references)

The effective pharmacological profile of Theo-24, as described in Health Canada’s monographs, includes its classification as a prescription medication for chronic respiratory conditions. It is known to rival other bronchodilators, primarily indicated in the treatment of asthma and COPD. Close monitoring of plasma theophylline levels is critical due to its narrow therapeutic range, as noted in official regulatory documents.

Indications & Off-Label Uses in Canada

Theo-24 is primarily indicated for the treatment of asthma, chronic bronchitis, and emphysema. These conditions fall under the umbrella of obstructive airway diseases, where theophylline contributes to long-term control of symptoms. Off-label uses, while commonplace in Canadian healthcare, reflect the diverse applications of this medication in treating respiratory issues beyond its formal indications.

Physicians might prescribe Theo-24 for off-label use in cases of nocturnal asthma or in patients who have not responded adequately to standard therapies. Also, it may be used in the management of respiratory conditions requiring additional bronchodilation in combination with inhaled medications.

Approved indications (DIN)

In Canada, Theo-24 is recognized for treating:

• Asthma: Used for long-term maintenance.
• Chronic bronchitis: Alleviates symptoms and improves airflow.
• Emphysema: Helps control shortness of breath.

Common off-label practices (Canadian physicians)

Canadian physicians frequently employ Theo-24 for off-label indications, including:

• Persistent cough associated with COPD.
• Nociceptive pain management in specific cases where traditional bronchodilators provide insufficient relief.
• Uncontrolled asthma where alternative treatments have failed.

Key Clinical Findings

Recent clinical studies both in Canada and internationally have underscored the efficacy of Theo-24 in enhancing respiratory function. Findings advocate for its use in adults, particularly those who find optimal control through combination therapies. Studies suggest that monitoring serum theophylline levels improves the safety and efficacy of treatment, allowing tailored adjustments that consider individual metabolic variations.

Moreover, research continues to affirm its role as a rescue and maintenance therapy, particularly in chronic asthma cases, showcasing both benefits and potential side effects, thus substantiating the need for ongoing patient education and monitoring.

Canadian and international studies 2022–2025

Key findings from 2022 to 2025 reveal a trend towards improved quality of life in patients utilizing Theo-24 as part of a controlled regimen. Reports highlight effective symptom management for chronic bronchitis, with enhanced pulmonary function noted in several trials involving comparative analyses with newer bronchodilator classes.

Ongoing Health Canada safety monitoring

Health Canada actively monitors the safety profile of Theo-24 alongside other medications, tracking reports of adverse effects and prescribing trends. This continuous surveillance ensures that updated safety information is available, advising healthcare providers and patients on best practices for usage.

Alternatives Matrix

When examining alternatives to Theo-24, various medications with similar indications can be considered. These alternatives include other bronchodilators and combinations that may or may not require prescription. It’s essential to evaluate the therapeutic effectiveness and side effect profile when considering switching medications.

Comparable medicines with DIN in Canada

The following medications can be compared to Theo-24 for their role in managing respiratory conditions:

• Aminophylline: Another xanthine-based bronchodilator.
• Dyphylline: Often used in place of theophylline in sensitive patients.
• LABAs and inhaled corticosteroids: More commonly used first-line treatments.

Pros and cons checklist

• Pros: Effective in long-term management; multiple dosage options available.
• Cons: Requires serum monitoring; potential side effects include nausea and jitteriness.

Common Questions from Canadian Patients

Patients often have questions regarding Theo-24 regarding its usage, side effects, and safety. Here are some common inquiries:

• Is it safe to use Theo-24 long-term? Yes, but regular monitoring is essential.
• Can I stop taking it suddenly? No, always consult a healthcare provider before discontinuing.
• How should I take Theo-24? It should be taken on an empty stomach for optimal absorption.

Suggested Visual Content

When it comes to the use of Theo-24, effective visual aids can significantly improve patient understanding and engagement. Providing clear and informative graphics can help demystify medication protocols for users.

• Infographics: Use infographics to represent the relationship between Theo-24 and provincial drug coverage plans. Highlight how various plans support patients.
• Flowcharts: Create step-by-step flowcharts that guide patients through obtaining Theo-24, whether from pharmacies or online platforms. Visual instructions are easier to follow and more engaging.
• Videos: Consider short, animated videos simplifying the medication's usage, storage, and available dosages, making it relatable and easier to digest.

Infographics on Provincial Drug Plan Coverage

Infographics can vividly illustrate how Theo-24 fits into provincial drug plans across Canada. Use colour coding to show the differences in coverage, including copayments and eligibility criteria. Such visualisations will enable patients to quickly grasp their options.

Canadian Pharmacy Purchase Flowcharts

Effective flowcharts can simplify the process of obtaining Theo-24. By visually mapping out the steps, patients can easily understand whether they should go through their pharmacy, online, or consult with a healthcare professional. These guides can also highlight points where patient support is available.

Registration & Regulation

Before Theo-24 can hit the market, several regulatory checks must be met. Health Canada plays a pivotal role in ensuring the medication is safe and effective for public use.

Health Canada Approval

The journey to getting Theo-24 approved by Health Canada involves extensive clinical trials and safety evaluations. This regulatory pathway ensures that the extended-release formulation holds its claims for efficacy, particularly for conditions like asthma and COPD.

DIN Number and Labelling Requirements

Drug Identification Numbers (DIN) are vital in Canada. They ensure that each medication, including Theo-24, can be tracked and verified within the healthcare system. Proper labelling, encompassing dosage, side effects, and contraindications, is crucial for patient safety and compliance.

Storage & Handling

For medications like Theo-24 to maintain their efficacy, proper storage and handling are imperative. Understanding the best practices can ensure patients remain safe while maximizing their treatment.

Standard Canadian Household Conditions

Storing Theo-24 should follow certain guidelines to maintain its potency:

• Store at room temperature between 15–30°C (59–86°F).
• Keep it in a dry, cool place away from direct sunlight and moisture.
• Always secure in the original packaging to minimize exposure to air.

Cold-Chain Requirements (Where applicable)

While Theo-24 doesn't generally require cold storage, it's essential to consult specific packaging and local guidelines for any variations that may apply.

Guidelines for Proper Use

Using Theo-24 as directed is essential for achieving the desired therapeutic effects. Here’s how patients can ensure they are getting the most out of their medication.

Canadian Pharmacist Guidance

Canadian pharmacists offer invaluable advice for those prescribed Theo-24:

• Consult about proper dosing and timing related to meals.
• Discuss potential side effects and what to expect while using the medication.
• Seek guidance on managing missed doses without doubling up, to avoid overdose risk.

Provincial Health Authority Recommendations

Different provinces have tailored guidelines for handling Theo-24. These might encompass when to return for follow-ups, monitoring plasma levels, and any additional interventions based on local health policies.

Delivery Information